Ligands for Target Protein for PROTAC
Target Protein-binding Moiety
The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).
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Ligands for Target Protein for PROTAC Inhibitors
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Ligands for Target Protein for PROTAC Chemicals
(6)
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Ligands for Target Protein for PROTAC Degrader
(1)
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Ligands for Target Protein for PROTAC Controls
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Ligands for Target Protein for PROTAC Ligands
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Ligands for Target Protein for PROTAC Related Products (688)
Related Products (688)
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Related Compound Screening Libraries (1)
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ALK ligand-1
0 ImagesCat. No.: HY-W754809CAS No.: 2353496-79-2
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PDK ligand-1
0 ImagesCat. No.: HY-184945CAS No.: 252016-13-0PDK ligand-1 (Compound 16) is a target protein ligand that serves as an HsClpP recruitment module for constructing mitochondrially targeted pan-PDK degraders. PDK ligand-1 can be used for the synthesis of Pan-PDK degrader-1 (HY-184943).
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KRAS G12C-IN-72
0 ImagesCat. No.: HY-128414CAS No.: 2326523-41-3KRAS G12C-IN-72 (Example 571) is a KRAS G12C inhibitor. KRAS G12C-IN-72 can be used as a target protein ligand to synthesize PROTACs, such as KRAS degrader-1 (HY-153880). KRAS G12C-IN-72 can be used in cancer research.
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ASK1 ligand 1
0 ImagesCat. No.: HY-174860CAS No.: 3064087-54-0ASK1 ligand 1 is a binding ligand for ASK1 and can be used to synthesize PROTACs such as dASK1-VHL (HY-174858)[1].
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DDR1 ligand 1
0 ImagesCat. No.: HY-176185DDR1 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). DDR1 ligand 1 can be used for the synthesis of PROTAC DDR1 degrader-1 (HY-176184).
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VP1 ligand-1
0 ImagesCat. No.: HY-183010CAS No.: 173900-00-0VP1 ligand-1 (Scheme 1 A 1) is a VP1 ligand. VP1 ligand-1 acts as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC) and is used for the development and design of PROTAC-based VP1 degraders, such as Jun15702 (HY-182924). VP1 ligand-1 is applicable to EV-D68 infection research.
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DHHC3 ligand 1
0 ImagesCat. No.: HY-169235DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232).
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AR ligand-37
0 ImagesCat. No.: HY-168697AR ligand-37 is a PROTAC target protein ligand that can be used to synthesize BMS-986365 (HY-158101).
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TH10184
0 ImagesCat. No.: HY-176262CAS No.: 2271044-59-6TH10184 is a NUDT5 inhibitor. TH10184 can be conjugated with VH032 (HY-125845) and linker (HY-W001958) to synthesize PROTAC NUDT5 degrader DDD2 (HY-176261).
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MK-5108-NH-PEG2-alkyne
0 ImagesCat. No.: HY-175827MK-5108-NH-PEG2-alkyne is a Aurora kinase A (AURKA) inhibitor. MK-5108-NH-PEG2-alkyne can be used for synthesis of PROTAC AURKA degrader 1 (HY-175830).
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KRASG12C ligand-2
0 ImagesCat. No.: HY-175583CAS No.: 2725905-93-9KRASG12C ligand-2 is a KRas ligand used for PROTAC synthesis. KRASG12C ligand-2 serves as the target protein ligand of PROTAC KRAS G12C degrader-2 (HY-153821).
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MI-2103
0 ImagesCat. No.: HY-131217CAS No.: 1410738-11-2MI-2103 is a MDM2 inhibitor with an IC50 of 48.1 nM. MI-2103 inhibits the growth of leukemia and breast cancer cells; it exerts no growth-inhibitory effect on cancer cells with p53 mutation or deletion. MI-2103 serves as a target protein ligand for the synthesis of MG-277 (HY-130122). MI-2103 is applicable to the research of leukemia and breast cancer.
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CDK9 ligand 3
0 ImagesCat. No.: HY-170979CAS No.: 3039540-24-1CDK9 ligand 3 is the ligand for CDK9 and can be used for synthesis of PROTAC degrader PROTAC CDK9 degrader-11 (HY-170978).
